From: hubermanlab
In a recent discussion between Dr. Andrew Huberman and Dr. Rena Malik, a variety of approaches to addressing issues of sexual function were explored. The focus was on both prescription medications and over-the-counter supplements, offering a broad overview that spans both medical treatments and lifestyle tweaks to enhance sexual health.
Prescription Medications
PDE5 Inhibitors
One of the most common classes of drugs discussed for improving sexual function is PDE5 inhibitors, which include Cialis (Tadalafil) and Viagra (Sildenafil). These medications work by increasing blood flow to the genitals, thereby improving erectile function in men. Effectiveness is high, with about 60-70% of men experiencing improved erections sufficient for penetrative intercourse ([00:54:58]).
Interestingly, daily low-dose Cialis (2.5 to 5 mg) is also used for prostate health and has off-label uses in women for increasing blood flow which can aid sexual function, though more research is needed in female applications ([00:56:03], [00:58:00]).
Dopaminergic Medications
Another approach involves dopamine-enhancing drugs, which can impact sexual desire differently. For example, Apomorphine is used in some places to enhance erectile function by influencing central dopaminergic pathways, although it is not widely used in the United States understanding dopamine’s role in motivation and satisfaction ([01:49:16]).
Supplements for Sexual Function
Dr. Malik and Dr. Huberman discussed various supplements that might support sexual health, noting that while medical data might be less robust, many individuals report benefits.
L-Citrulline
Often mentioned in discussions about natural remedies for erectile dysfunction, L-citrulline can increase nitric oxide levels, aiding in vasodilation and blood flow typically without the side effects associated with PDE5 inhibitors. However, users should be cautious as some might experience side effects like cold sores ([00:52:55]).
Tongkat Ali and Maca Root
Both Tongkat Ali and Maca Root are herbal supplements that are frequently discussed in the context of libido enhancement. Tongkat Ali may help by modulating stress hormones like cortisol and increasing free testosterone, whereas Maca Root is believed to enhance sexual wellbeing and hormonal balance indirectly hormone optimization tools ([02:45:36], [02:46:06]).
Shilajit
Shilajit, an Ayurvedic substance, is gaining traction for potential benefits in increasing follicle-stimulating hormone and improving stress resilience, which could indirectly support sexual health role of emotions and the nervous system ([02:46:22]).
Exercise and Lifestyle
Both Dr. Malik and Dr. Huberman emphasized behavioral interventions like regular exercise, maintaining a healthy diet, and ensuring adequate sleep as foundational for sexual health. These lifestyle choices can naturally support hormone health and enhance vascular function, which are critical to a healthy sexual response ([02:47:14]).
Conclusion
While prescription drugs like PDE5 inhibitors offer effective solutions for many with erectile dysfunction, there is a growing interest and often positive anecdotal support for supplements like L-citrulline, Tongkat Ali, Maca Root, and Shilajit supplements for enhancing libido and desire. However, Dr. Malik cautions against viewing these supplements as cure-alls and recommends lifestyle changes as the first line of defense to support sexual health naturally. The complex interplay of mind, body, and supplementation makes a holistic approach essential in the realm of sexual well-being.